Xarelto May Cause More Bleeding Than Pradaxa

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According to an observational study published in JAMA Internal Medicine, people taking Xarelto (rivaroxaban) may be more likely to have a serious bleeding event than those taking Pradaxa (dabigatran). Johnson and Johnson (J&J) is facing more the 15,000 Xarelto lawsuits.

The Study

For the study, researchers looked at the records of 118,000 Medicare patients with atrial fibrillation (AFib), who took either Xarelto or Pradaxa. Researchers found that there were more serious bleeding events in those taking Xarelto than those taking Pradaxa. This included intracranial hemorrhage, meaning bleeding in the brain, and extracranial bleeding events including major gastrointestinal bleeding.

The researchers also noted that, in 2014, rivaroxaban was prescribed two to three times more often than dabigatran for AFib patients in the U.S., and they said that may be due to doctors falsely believing that Xarelto posed less risk of major bleeding events than Pradaxa.

Xarelto is in a class of drugs called novel oral anticoagulants (NOACs). Other NOACs include Pradaxa, Eliquis (apixaban), and Savaysa (edoxaban). Currently, NOACs are used to reduce the risk of stroke in people with AFib. All carry the risk of causing major bleeding events. A reversal agent for Pradaxa was recently approved. There is no antidote for Xarelto, Eliquis, or Savaysa.Xarelto bleeding is so dangerous because there is no quick way for emergency room doctors to get it under control. Even with immediate medical attention, a Xarelto user can bleed out before treatments can be effective.